We are still in the primary stages of designing and implementing a regional cultural policy, despite the fact that the need for such a policy is obvious, and that the restructuring of resources has already begun. In order to address this issue, not so much from the limiting perspective of bureaucratic rigidity but, mainly, through a cultural analysis approach, we will look at the re-conceptualization of resources, organization, economy and management, through successful case studies, which yielded improved results. The design and implementation of a regional cultural policy will not only act as a relief, but may also have more ambitious positive effects in terms of restructuring the identity and visibility of cities and regions, cultural cohesion, the  inclusion of marginalized population groups, and economic revitalization as a result of previously unacknowledged and/or undervalued resources, possibly delivering high levels of added value. Inclusive participatory processes are therefore necessary, in a spirit of solidarity, in order to support the emerging powers of each region, and to encourage them to undertake joint initiatives, with an attitude of extroversion and a sense of responsibility.